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KMID : 1149220100180010079
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Korean Journal of Oriental Medical Prescription
2010 Volume.18 No. 1 p.79 ~ p.85
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Acute Toxicity Study on Gumiganghwal-tang(Jiuweiqianghuo-tang) in Sprague-Dawley Rats
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Shin In-Sik
Kim Jung-Hoon
Ha Hye-Kyung
Seo Chang-Seob
Lee Mee-Young
Lee Ho-Young
Lee Jun-Kyoung
Lee Nam-Hun
Lee Jin-Ah
Lee Sul-Lim
Huh Jung-Im
Shin Hyeun-Kyoo
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Abstract
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Objectives:This study was conducted to evaluate the acute toxicity and safety of Gumiganghwal-tang (Jiuweiqianghou-tang) in Sprague-Dawley rats though the current regulatory guideline.
Methods:The preliminary study showed that the single oral administration of Gumiganghwal-tang(Jiuweiqianghou-tang) did not induce any toxic effect at a dose level of 2000 mg/kg. Based on the results, 2000 mg/kg was selected as the limited dose. In this study, 10 rats of each sex were randomly assigned to two groups of 5 rats each and were administrated singly by gavage at dose levels of 0 and 2000 mg/kg. Mortalities, clinical signs, and body weight changes were monitored for the 15-day period following administration. At the end of observation period, all animals were sacrificed and complete gross postmortem examinations were performed.
Results:Throughout the study period, no treatment-related deaths were observed. There were no adverse effects on clinical signs, body weight, and gross findings at all treatment groups.
Conclusions:These results showed that the single oral adminstration of Gumiganghwal-tang(Jiuweiqianghou-tang) did not cause any toxic effect at the dose levels of 2000 mg/kg in rats. In conclusion, the of Gumiganghwal-tang (Jiuweiqianghou-tang) was considered to be over 2000 mg/kg body for both sexes.
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KEYWORD
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Gumiganghwal-tang(Jiuweiqianghou-tang), Acute toxicity, Safety, LD50 , Rats
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